A common question in regards of OneDrive For Business (ODFB) is about how to delete a ODFB site in Office 365. Fortunately, this question has a simple answer: just use PowerShell. Indeed, using Remove-SPOSite you can easily delete an existing ODFB site as described in the following PowrShell script:
If you run this PowerShell script in the SharePoint Online (SPO) Administration Console, you will see how the script is executed without problems:
Using Get-SPOSite you can verify that the ODFB site is not existing anymore:
Finally, if end user try to access his/her ODFB site, he will see that the ODFB site is going to be provisioned from scratch.